Abstract
Lysyl-tRNA synthetase isolated from rat liver cleaves glycosidic bond of 5-Fluorouridine and 5-Fluoro-2'-deoxyuridine to generate 5-Fluorouracil. The generation of 5-Fluorouracil was monitored by cellulose thin layer chromatography and by spectrophotometry. The enzyme was found to be 1.4 fold more efficient in cleaving the glycosidic bond of 5-Fluoro-2'-deoxyuridine than 5-Fluorouridine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromatography, Thin Layer
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Cytoplasm / enzymology
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Floxuridine / metabolism*
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Glycoside Hydrolases / metabolism
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Glycosides / metabolism*
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Hydrolysis
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Liver / enzymology
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Lysine-tRNA Ligase / metabolism*
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Rats
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Rats, Inbred Strains
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Uridine / analogs & derivatives*
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Uridine / metabolism
Substances
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Glycosides
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Floxuridine
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5-fluorouridine
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Glycoside Hydrolases
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Lysine-tRNA Ligase
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doxifluridine
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Uridine