Abstract
Nine oxygenated cyclohexanoids, speciosins L-T (1-9) as well as a 5H-furan-2-one metabolite, 5'-O-acetylaporpinone A (10), together with known analogs, speciosins A, B, D, E, F, I and K (11-17), and aporpinone A (18), were isolated from a scale-up cultures of the basidiomycete Hexagonia speciosa. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR. Speciosin B (12) showed significant cytotoxicity against several tumor cell lines with IC50 values in the range 0.23-3.30 μM.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Basidiomycota / chemistry*
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Cell Line, Tumor
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Cyclohexanols / chemistry*
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Cyclohexanols / isolation & purification
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Cyclohexanones / chemistry*
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Cyclohexanones / isolation & purification
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Drug Screening Assays, Antitumor
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Humans
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Hydrocarbons, Cyclic / chemistry*
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Hydrocarbons, Cyclic / isolation & purification
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Inhibitory Concentration 50
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Molecular Structure
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Prenylation
Substances
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Antineoplastic Agents
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Cyclohexanols
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Cyclohexanones
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Hydrocarbons, Cyclic
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speciosin B