Isoprenylated cyclohexanoids from the basidiomycete Hexagonia speciosa

Phytochemistry. 2011 Jun;72(9):923-8. doi: 10.1016/j.phytochem.2011.03.011. Epub 2011 Apr 7.

Abstract

Nine oxygenated cyclohexanoids, speciosins L-T (1-9) as well as a 5H-furan-2-one metabolite, 5'-O-acetylaporpinone A (10), together with known analogs, speciosins A, B, D, E, F, I and K (11-17), and aporpinone A (18), were isolated from a scale-up cultures of the basidiomycete Hexagonia speciosa. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR. Speciosin B (12) showed significant cytotoxicity against several tumor cell lines with IC50 values in the range 0.23-3.30 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Basidiomycota / chemistry*
  • Cell Line, Tumor
  • Cyclohexanols / chemistry*
  • Cyclohexanols / isolation & purification
  • Cyclohexanones / chemistry*
  • Cyclohexanones / isolation & purification
  • Drug Screening Assays, Antitumor
  • Humans
  • Hydrocarbons, Cyclic / chemistry*
  • Hydrocarbons, Cyclic / isolation & purification
  • Inhibitory Concentration 50
  • Molecular Structure
  • Prenylation

Substances

  • Antineoplastic Agents
  • Cyclohexanols
  • Cyclohexanones
  • Hydrocarbons, Cyclic
  • speciosin B