Abstract
Oestrogens regulate normal behaviour and have been implicated in modulating pathological behaviour such as obsessive compulsive disorder and neurological disorder such as Parkinsonism. Therefore, by regulating the expression of the oestrogen-synthesising enzyme, aromatase, we may identify what behaviour is regulated by oestrogen. Inhibition of aromatase either genetically or pharmacologically has been reported to induce sexual behaviour impairment, compulsive behaviour and susceptibility to neurodegeneration.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Aromatase / genetics
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Aromatase / metabolism*
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Aromatase Inhibitors / adverse effects*
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Aromatase Inhibitors / therapeutic use
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Estrogens / biosynthesis*
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Estrogens / genetics
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Estrogens / metabolism
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Gene Expression Regulation
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Humans
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Learning / drug effects
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Mice
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Mice, Knockout
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Obsessive-Compulsive Disorder / chemically induced*
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Obsessive-Compulsive Disorder / enzymology
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Parkinsonian Disorders / chemically induced*
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Parkinsonian Disorders / enzymology
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Sexual Behavior, Animal / drug effects
Substances
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Aromatase Inhibitors
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Estrogens
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Aromatase