Autophagy in Ras-induced malignant transformation: fatal or vital?

Guillermo Mariño; Isabelle Martins; Guido Kroemer

doi:10.1016/j.molcel.2011.03.003

Autophagy in Ras-induced malignant transformation: fatal or vital?

Mol Cell. 2011 Apr 8;42(1):1-3. doi: 10.1016/j.molcel.2011.03.003.

Authors

Guillermo Mariño¹, Isabelle Martins, Guido Kroemer

Affiliation

¹ INSERM, U848, F-94805 Villejuif, France.

PMID: 21474062
DOI: 10.1016/j.molcel.2011.03.003

Abstract

In this issue of Molecular Cell, Elgendy et al. suggest that Ras-induced autophagy may kill tumor cells on the verge of oncogenic transformation, providing a contrast to recent reports indicating that autophagy is required for optimal growth of Ras-driven cancers.

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