This study evaluated the effect of cigarette smoke combined or not with colored beverages on the color change of a composite resin before and after repolishing procedures. Composite specimens were allocated into six groups (N = 10): 1) control (no colorant); 2) cigarette smoke; 3) coffee; 4) coffee and cigarette smoke; 5) red wine; and 6) red wine and cigarette smoke. During 21 days, groups 2, 4, and 6 were exposed daily to the smoke from 20 cigarettes, and groups 3, 4, 5, and 6 were immersed in coffee or red wine for 4 minutes each day. Color measurements were performed with a spectrophotometer at baseline, after 21 days, and after repolishing procedures. Statistical analysis indicated the exposure to cigarette smoke and staining beverages resulted in decreased luminosity (P = .0001) and increased red pigmentation in most experimental groups (P < .05). In groups 3, 4, and 6, an increased yellowish coloration (P = .001) was observed. Irrespective of the experimental group, total color changes were clinically significant (AE > 7.5). Repolishing resulted in greater luminosity, as well as decreased yellow pigmentation (P < .05). It could be concluded that combined staining agents such as cigarette smoke and red wine irreversibly change resin color regardless of the use of repolishing procedures.