Abstract
Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1- 2) and four known (3- 6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Brazil
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Cell Line, Tumor
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Cell Survival
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Chromatography, High Pressure Liquid
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Cucurbitaceae / chemistry*
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Cucurbitacins / chemistry
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Cucurbitacins / isolation & purification
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Cucurbitacins / pharmacology*
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Humans
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Medicine, Traditional
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Roots / chemistry
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Plants, Medicinal
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Spectrometry, Mass, Electrospray Ionization
Substances
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Plant Extracts
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Cucurbitacins