New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn

Planta Med. 2011 Sep;77(14):1648-51. doi: 10.1055/s-0030-1270962. Epub 2011 Apr 6.

Abstract

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1- 2) and four known (3- 6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brazil
  • Cell Line, Tumor
  • Cell Survival
  • Chromatography, High Pressure Liquid
  • Cucurbitaceae / chemistry*
  • Cucurbitacins / chemistry
  • Cucurbitacins / isolation & purification
  • Cucurbitacins / pharmacology*
  • Humans
  • Medicine, Traditional
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Roots / chemistry
  • Plants, Medicinal
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Plant Extracts
  • Cucurbitacins