Hepatitis a virus vaccine escape variants and potential new serotype emergence

Unai Pérez-Sautu; M Isabel Costafreda; Joan Caylà; Cecilia Tortajada; Josep Lite; Albert Bosch; Rosa M Pintó

doi:10.3201/eid1704.101169

Hepatitis a virus vaccine escape variants and potential new serotype emergence

Emerg Infect Dis. 2011 Apr;17(4):734-7. doi: 10.3201/eid1704.101169.

Authors

Unai Pérez-Sautu¹, M Isabel Costafreda, Joan Caylà, Cecilia Tortajada, Josep Lite, Albert Bosch, Rosa M Pintó

Affiliation

¹ University of Barcelona, Barcelona, Spain.

Abstract

Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men. The need to complete the proper vaccination schedules is critical, particularly in the immunocompromised population, to prevent the emergence of vaccine-escaping variants.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Substitution
Antigenic Variation / immunology
Hepatitis A / classification
Hepatitis A / virology*
Hepatitis A Vaccines*
Hepatitis A virus / genetics*
Hepatitis A virus / immunology
Humans
Immunocompromised Host / immunology
Male
Mutation / genetics
Phylogeny
Vaccination
Viral Structural Proteins / genetics

Substances

Hepatitis A Vaccines
VP1 protein, hepatitis A virus
Viral Structural Proteins