Syntheses and biological activities of 1,4-iminoalditol derivatives as alpha-L-fucosidase inhibitors

Elena Moreno-Clavijo; Ana T Carmona; Antonio J Moreno-Vargas; Lidia Molina; Inmaculada Robina

doi:10.2533/chimia.2011.40

Syntheses and biological activities of 1,4-iminoalditol derivatives as alpha-L-fucosidase inhibitors

Chimia (Aarau). 2011;65(1-2):40-4. doi: 10.2533/chimia.2011.40.

Authors

Elena Moreno-Clavijo¹, Ana T Carmona, Antonio J Moreno-Vargas, Lidia Molina, Inmaculada Robina

Affiliation

¹ Dept. Organic Chemistry, Faculty of Chemistry, University of Seville, P.O. Box 1203, E-41071 Seville, Spain.

PMID: 21469443
DOI: 10.2533/chimia.2011.40

Abstract

A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of alpha-L-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Imino Furanoses / chemical synthesis*
Imino Furanoses / chemistry
Imino Furanoses / pharmacology*
Molecular Structure
Stereoisomerism
Structure-Activity Relationship
alpha-L-Fucosidase / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Imino Furanoses
alpha-L-Fucosidase