Triterpenoids and diterpenoids from Viburnum chingii

Chem Pharm Bull (Tokyo). 2011;59(4):496-8. doi: 10.1248/cpb.59.496.

Abstract

Two new oleanane triterpenoids (1-2) and one new vibsane-type diterpenoid (3), together with 7 known compounds (4-10), were isolated from the leaves of Viburnum chingii. The structures of compounds 1-3 were elucidated by means of spectroscopic methods including extensive 1D- and 2D-NMR technique. Cytotoxicity of compounds 1-10 were tested against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 cell lines. Compound 3 showed significant cytotoxicity against HL-60, SK-BR-3, and PANC-1 cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / toxicity
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Diterpenes / toxicity
  • Drug Screening Assays, Antitumor
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Oleanolic Acid / chemistry*
  • Oleanolic Acid / isolation & purification
  • Oleanolic Acid / pharmacology
  • Oleanolic Acid / toxicity
  • Plant Leaves / chemistry
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / toxicity
  • Viburnum / chemistry*

Substances

  • 1alpha,3beta-dihydroxy-11a -methoxy-olean-12-ene
  • 1alpha,3beta-dihydroxy-olean-9(11),12-dien
  • 2alpha,3beta -dihydroxy-20(29)-lupene
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Triterpenes
  • Oleanolic Acid