[Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo]

Yao Xue Xue Bao. 2011 Jan;46(1):70-4.
[Article in Chinese]

Abstract

To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by 1H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Male
  • Molecular Structure
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / chemical synthesis*
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / pharmacology*
  • Purinergic P2Y Receptor Antagonists / chemical synthesis
  • Purinergic P2Y Receptor Antagonists / chemistry
  • Purinergic P2Y Receptor Antagonists / pharmacology
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Thienopyridines / chemical synthesis*
  • Thienopyridines / chemistry
  • Thienopyridines / pharmacology*

Substances

  • Platelet Aggregation Inhibitors
  • Purinergic P2Y Receptor Antagonists
  • Thienopyridines