Identification of drug targets in vitro and in living cells by soluble-nanopolymer-based proteomics

Angew Chem Int Ed Engl. 2011 Apr 26;50(18):4133-6. doi: 10.1002/anie.201006459. Epub 2011 Mar 31.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cell Line, Tumor
  • Dendrimers / chemistry*
  • Drug Discovery / methods*
  • Fluorescein-5-isothiocyanate / chemistry
  • Humans
  • Methotrexate / pharmacology
  • Microscopy, Fluorescence
  • Molecular Sequence Data
  • Nanotechnology
  • Proteomics*
  • Tandem Mass Spectrometry
  • Tetrahydrofolate Dehydrogenase / chemistry
  • Tetrahydrofolate Dehydrogenase / metabolism

Substances

  • Dendrimers
  • PAMAM Starburst
  • Tetrahydrofolate Dehydrogenase
  • Fluorescein-5-isothiocyanate
  • Methotrexate