New cathepsin inhibitors to explore the fluorophilic properties of the S2 pocket of cathepsin B: design, synthesis, and biological evaluation

Chemistry. 2011 May 2;17(19):5256-60. doi: 10.1002/chem.201100113. Epub 2011 Mar 30.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cathepsin B / antagonists & inhibitors*
  • Combinatorial Chemistry Techniques
  • Dipeptides / chemical synthesis*
  • Dipeptides / chemistry
  • Dipeptides / pharmacology*
  • Drug Design*
  • Humans
  • Hydrocarbons, Fluorinated / chemical synthesis*
  • Hydrocarbons, Fluorinated / chemistry
  • Hydrocarbons, Fluorinated / pharmacology*
  • Molecular Structure
  • Nitriles / chemical synthesis*
  • Nitriles / chemistry
  • Nitriles / pharmacology*
  • Stereoisomerism

Substances

  • Dipeptides
  • Hydrocarbons, Fluorinated
  • Nitriles
  • Cathepsin B