Abstract
Endosome-escapable poly(amino acid) nanoparticles composed of iron oxide nanocrystals and anticancer drugs were prepared and demonstrated high T(2) relaxivity coefficients and higher efficacy attributed to the endosomolytic ability of the conjugated histidine moiety.
© The Royal Society of Chemistry 2011
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry*
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Amino Acids / therapeutic use*
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Doxorubicin / chemistry*
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Endosomes / chemistry*
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Endosomes / metabolism*
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Ferric Compounds / chemistry*
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HeLa Cells
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Histidine / chemistry*
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Humans
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Magnetic Resonance Spectroscopy
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Metal Nanoparticles
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Nanoparticles / chemistry*
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Neoplasms / diagnosis*
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Neoplasms / drug therapy*
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Particle Size
Substances
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Amino Acids
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Ferric Compounds
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ferric oxide
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Histidine
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Doxorubicin