Endosome-escapable magnetic poly(amino acid) nanoparticles for cancer diagnosis and therapy

Chem Commun (Camb). 2011 May 14;47(18):5322-4. doi: 10.1039/c1cc10371g. Epub 2011 Mar 30.

Abstract

Endosome-escapable poly(amino acid) nanoparticles composed of iron oxide nanocrystals and anticancer drugs were prepared and demonstrated high T(2) relaxivity coefficients and higher efficacy attributed to the endosomolytic ability of the conjugated histidine moiety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Amino Acids / therapeutic use*
  • Doxorubicin / chemistry*
  • Endosomes / chemistry*
  • Endosomes / metabolism*
  • Ferric Compounds / chemistry*
  • HeLa Cells
  • Histidine / chemistry*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Metal Nanoparticles
  • Nanoparticles / chemistry*
  • Neoplasms / diagnosis*
  • Neoplasms / drug therapy*
  • Particle Size

Substances

  • Amino Acids
  • Ferric Compounds
  • ferric oxide
  • Histidine
  • Doxorubicin