Abstract
Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / pharmacology*
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Chemoprevention*
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Chlorogenic Acid / pharmacology*
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Coffee / chemistry*
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Enzyme Induction / drug effects
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Glutamate-Cysteine Ligase / biosynthesis
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HT29 Cells
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Heme Oxygenase-1 / biosynthesis
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Humans
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NF-E2-Related Factor 2 / physiology*
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Pyridinium Compounds / pharmacology*
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Reactive Oxygen Species / metabolism
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Response Elements / physiology*
Substances
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Antioxidants
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Coffee
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NF-E2-Related Factor 2
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NFE2L2 protein, human
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Pyridinium Compounds
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Reactive Oxygen Species
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Chlorogenic Acid
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1-methylpyridinium
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HMOX1 protein, human
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Heme Oxygenase-1
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Glutamate-Cysteine Ligase