New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus

J Antibiot (Tokyo). 2011 Jun;64(6):461-3. doi: 10.1038/ja.2011.24. Epub 2011 Mar 30.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology*
  • Benzoquinones / chemistry
  • Benzoquinones / isolation & purification
  • Benzoquinones / pharmacology*
  • Cell Line, Tumor
  • Genetic Engineering
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors*
  • Humans
  • Lactams, Macrocyclic / chemistry
  • Lactams, Macrocyclic / isolation & purification
  • Lactams, Macrocyclic / pharmacology*
  • Streptomyces / genetics
  • Streptomyces / metabolism*

Substances

  • Antibiotics, Antineoplastic
  • Benzoquinones
  • DHQ3 compound
  • DHQ7 compound
  • DHQ8 compound
  • HSP90 Heat-Shock Proteins
  • Lactams, Macrocyclic
  • Adenosine Triphosphatases
  • geldanamycin