Gut microbiota, probiotics and inflammatory bowel disease

Johannes Stephani; Katarina Radulovic; Jan Hendrik Niess

doi:10.1007/s00005-011-0122-5

Gut microbiota, probiotics and inflammatory bowel disease

Arch Immunol Ther Exp (Warsz). 2011 Jun;59(3):161-77. doi: 10.1007/s00005-011-0122-5. Epub 2011 Mar 29.

Authors

Johannes Stephani¹, Katarina Radulovic, Jan Hendrik Niess

Affiliation

¹ Department of Internal Medicine I, Ulm University, Helmholtzstr, 8/1, 89031, Ulm, Germany.

PMID: 21445715
DOI: 10.1007/s00005-011-0122-5

Abstract

The colonization of humans with commensals is critical for our well-being. This tightly regulated symbiotic relationship depends on the flora and an intact mucosal immune system. A disturbance of either compound can cause intestinal inflammation. This review summarizes extrinsic and intrinsic factors contributing to intestinal dysbiosis and inflammatory bowel disease.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Environmental Exposure / adverse effects
Genetic Predisposition to Disease
Humans
Immunity, Mucosal
Immunomodulation
Inflammatory Bowel Diseases / etiology
Inflammatory Bowel Diseases / immunology*
Inflammatory Bowel Diseases / microbiology
Intestinal Mucosa / microbiology*
Probiotics / metabolism*
Symbiosis