Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

Lingling Peng; Joseph DeSousa; Zhaoming Su; Bruce M Novak; Alexander A Nevzorov; Eva R Garland; Christian Melander

doi:10.1039/c1cc10691k

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

Chem Commun (Camb). 2011 May 7;47(17):4896-8. doi: 10.1039/c1cc10691k. Epub 2011 Mar 25.

Authors

Lingling Peng¹, Joseph DeSousa, Zhaoming Su, Bruce M Novak, Alexander A Nevzorov, Eva R Garland, Christian Melander

Affiliation

¹ North Carolina State University, Department of Chemistry, Raleigh, North Carolina, 27695-8204, USA.

PMID: 21442111
DOI: 10.1039/c1cc10691k

Abstract

A polymeric composite containing a 2-aminoimidazole derivative was synthesized. It was found that this polymer was resistant to biofilm colonization by Acinetobacter baumannii, no leaching of the 2-aminoimidazole derivative was observed after 2 weeks of treatment with deionized water, and the resulting polymer was not hemolytic.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Acinetobacter Infections / microbiology
Acinetobacter baumannii / drug effects*
Acinetobacter baumannii / growth & development
Anti-Infective Agents* / chemical synthesis
Anti-Infective Agents* / pharmacology
Biofilms / drug effects
Gentian Violet / analysis
Imidazoles* / chemical synthesis
Imidazoles* / pharmacology
Methacrylates / chemistry
Polymers / chemistry

Substances

Anti-Infective Agents
Imidazoles
Methacrylates
Polymers
2-aminoimidazole
Gentian Violet