Individual and joint action of environmental factors and risk of MS

I A F van der Mei; S Simpson Jr; J Stankovich; B V Taylor

doi:10.1016/j.ncl.2010.12.007

Individual and joint action of environmental factors and risk of MS

Neurol Clin. 2011 May;29(2):233-55. doi: 10.1016/j.ncl.2010.12.007.

Authors

I A F van der Mei¹, S Simpson Jr, J Stankovich, B V Taylor

Affiliation

¹ Menzies Research Institute, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia 7000. Ingrid.vanderMei@utas.edu.au

PMID: 21439439
DOI: 10.1016/j.ncl.2010.12.007

Abstract

In this review, the evidence for the leading environmental and lifestyle factors thought to play a role in multiple sclerosis (MS) onset, including Epstein-Barr virus, sun exposure or vitamin D, and smoking, will be discussed. The Causal Pie Model is used as a conceptual framework to understand the causation. Given that no single factor leads to the development of MS, the joint action or interaction of these factors, along with genetic factors, most particularly the HLA-DR15*1501 genotype, is a primary focus.

Publication types

Review

MeSH terms

Environment*
Epstein-Barr Virus Infections / complications
Genetic Predisposition to Disease*
Humans
Models, Biological
Multiple Sclerosis / etiology*
Multiple Sclerosis / genetics
Risk Factors
Smoking / physiopathology*
Vitamins / metabolism

Substances

Vitamins