Palladium-catalyzed C,N-cross coupling reactions of 3-halo-2-aminopyridines

Org Lett. 2011 Apr 15;13(8):1984-7. doi: 10.1021/ol200371n. Epub 2011 Mar 25.

Abstract

A simple approach toward N(3)-substituted-2,3-diaminopyridines is presented, based on Pd-catalyzed C,N-cross coupling. The use of RuPhos- and BrettPhos-precatalysts in combination with LiHMDS allows for C,N-cross coupling reactions of unprotected 3-halo-2-aminopyridines with primary and secondary amines.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amination
  • Aminopyridines / chemistry*
  • Carbon / chemistry*
  • Catalysis
  • Cross-Linking Reagents / chemistry*
  • Ligands
  • Molecular Structure
  • Nitrogen / chemistry*
  • Palladium / chemistry*

Substances

  • Aminopyridines
  • Cross-Linking Reagents
  • Ligands
  • Palladium
  • Carbon
  • Nitrogen