Koebner's phenomenon in systemic lupus erythematosus

Rheumatol Int. 2012 May;32(5):1403-5. doi: 10.1007/s00296-011-1864-4. Epub 2011 Mar 25.

Abstract

Koebner phenomenon is defined as a nonspecific skin stimulus eliciting a disease skin reaction. The nature of the skin trauma varies greatly and includes areas of thermal injury, excoriations, surgical incisions, and scars. We report a patient with recent onset of systemic lupus erythematosus who developed Herpes zoster on immunosuppressant medication. Two weeks after resolution of the vesicles, the patient presented with new ulcerative reddish lesions over the herpes zoster scare and worsening of her malar rash without evidence of worsening of any other organ. Koebner phenomenon was suspected. We review the literature on Koebner phenomenon in SLE.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acyclovir / therapeutic use
  • Adolescent
  • Antiviral Agents / therapeutic use
  • Female
  • Herpes Zoster / complications*
  • Herpes Zoster / drug therapy
  • Herpes Zoster / pathology
  • Herpes Zoster / virology
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Lupus Erythematosus, Discoid / diagnosis
  • Lupus Erythematosus, Discoid / drug therapy
  • Lupus Erythematosus, Discoid / etiology*
  • Lupus Erythematosus, Discoid / pathology
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / drug therapy*
  • Skin / drug effects
  • Skin / immunology
  • Skin / pathology*

Substances

  • Antiviral Agents
  • Immunosuppressive Agents
  • Acyclovir