The adaptive stroma joining the antiangiogenic resistance front

J Clin Invest. 2011 Apr;121(4):1244-7. doi: 10.1172/JCI46430. Epub 2011 Mar 23.

Abstract

Resistance to antiangiogenic therapies in cancer involves both tumor cells and stromal components, but their relative contributions differ in each cancer subtype. In this issue of the JCI, Cascone et al. describe a stromal adaptation to antiangiogenic therapy in non-small cell lung carcinoma (NSCLC) models that include EGFR-driven vascular remodeling promoting resistance to VEGF inhibition. Their results suggest that the added benefit of dual VEGF/R and EGFR targeting in these models could be clinically relevant to fight resistance in NSCLC patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adaptation, Physiological
  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Carcinoma, Non-Small-Cell Lung / blood supply
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Drug Resistance, Neoplasm / physiology*
  • ErbB Receptors / antagonists & inhibitors
  • Humans
  • Lung Neoplasms / blood supply
  • Lung Neoplasms / drug therapy
  • Models, Biological
  • Neoplasms / blood supply
  • Neoplasms / drug therapy
  • Neoplasms / physiopathology
  • Neovascularization, Pathologic / drug therapy
  • Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors
  • Stromal Cells / drug effects
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors

Substances

  • Angiogenesis Inhibitors
  • Vascular Endothelial Growth Factor A
  • ErbB Receptors
  • Receptors, Vascular Endothelial Growth Factor