Sericulture in India is a highly remunerative industry, especially for the rural population. Mulberry is an extremely versatile plant, having multifaceted applications, the most important being the sole feed for the monophagus silkworm, Bombyx mori. Profitability of the sericulture industry is directly correlated with production of high-quality mulberry leaves. However, mulberry productivity is severely impacted by abiotic as well as biotic stresses. Therefore, to develop stress-tolerant mulberry with desired characteristics, a comprehensive understanding and utility of biotechnological resources is essential. Research efforts on mulberry encompass broad range of fields in plant biology from breeding, molecular markers, transcriptomics, proteomics, and metabolomics. Additionally, a large number of mulberry germplasm accessions have been maintained and evaluated in several countries. Identification of superior cultivars under stressed regimes is extremely important, and therefore, physiological traits have often been used as proxy genetic markers for assessing stress tolerance index. Mulberry genomic resources have provided a limited but an important list of novel candidate genes, thus enhancing the scope for future investigations for improvement of its productivity. The present review article gives a bird's eye view of current initiatives of genomics advancements in mulberry research and enumerates the prospects for enhancing its productivity.