Abstract
The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form.
© The Royal Society of Chemistry 2011
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / metabolism
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Benzophenanthridines / chemistry
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Benzophenanthridines / metabolism*
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Berberine / chemistry
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Berberine / metabolism*
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Binding Sites
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Crystallization
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Crystallography, X-Ray
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DNA / chemistry
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DNA / metabolism*
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Intercalating Agents / chemistry
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Intercalating Agents / metabolism
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Isoquinolines / chemistry
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Isoquinolines / metabolism*
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Models, Molecular
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Nucleic Acid Conformation
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Oligodeoxyribonucleotides / chemistry
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Oligodeoxyribonucleotides / metabolism
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X-Ray Diffraction
Substances
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Anti-Infective Agents
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Benzophenanthridines
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Intercalating Agents
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Isoquinolines
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Oligodeoxyribonucleotides
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Berberine
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DNA
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sanguinarine