Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function

Future Med Chem. 2011 Feb;3(2):243-50. doi: 10.4155/fmc.10.302.

Abstract

We discuss the potential use of multicomponent reactions in developing small-molecule probes of GABA(A) receptor function. Two examples that illustrate this approach are presented: the synthesis of a class of compounds that specifically modulate the function of GABA(A) receptors containing the δ-subunit, and also 'caged' GABA derivatives. A caged GABA is a photolabile precursor of GABA that releases GABA upon photolysis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • HEK293 Cells
  • Humans
  • Molecular Structure
  • Photochemistry / methods
  • Photolysis
  • Pyrimidinones / chemical synthesis
  • Pyrimidinones / chemistry
  • Receptors, GABA-A / chemistry
  • Receptors, GABA-A / metabolism*
  • gamma-Aminobutyric Acid / chemistry*
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Pyrimidinones
  • Receptors, GABA-A
  • gamma-Aminobutyric Acid