Chisomicines A-C, limonoids from Chisocheton ceramicus

Ibrahim A Najmuldeen; A Hamid A Hadi; Khalijah Awang; Khalit Mohamad; Kamal Aziz Ketuly; Mat Ropi Mukhtar; Soon-Lim Chong; Gomathi Chan; Mohd Azlan Nafiah; Ng Seik Weng; Osamu Shirota; Takahiro Hosoya; Alfarius E Nugroho; Hiroshi Morita

doi:10.1021/np200013g

Chisomicines A-C, limonoids from Chisocheton ceramicus

J Nat Prod. 2011 May 27;74(5):1313-7. doi: 10.1021/np200013g. Epub 2011 Mar 23.

Authors

Ibrahim A Najmuldeen¹, A Hamid A Hadi, Khalijah Awang, Khalit Mohamad, Kamal Aziz Ketuly, Mat Ropi Mukhtar, Soon-Lim Chong, Gomathi Chan, Mohd Azlan Nafiah, Ng Seik Weng, Osamu Shirota, Takahiro Hosoya, Alfarius E Nugroho, Hiroshi Morita

Affiliation

¹ Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

PMID: 21428417
DOI: 10.1021/np200013g

Abstract

Three new limonoids, chisomicines A-C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated by LPS dose-dependently at high cell viability.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Crystallography, X-Ray
Dose-Response Relationship, Drug
Limonins / chemistry
Limonins / isolation & purification*
Limonins / pharmacology
Lipopolysaccharides / pharmacology
Malaysia
Meliaceae / chemistry*
Mice
Models, Molecular
Molecular Structure
Nitric Oxide / antagonists & inhibitors
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
omega-N-Methylarginine / pharmacology

Substances

Limonins
Lipopolysaccharides
chisomicine A
chisomicine B
chisomicine C
omega-N-Methylarginine
Nitric Oxide