Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia

Wai-Sum Yap; Chew-Yan Gan; Yun-Yee Low; Yeun-Mun Choo; Tadahiro Etoh; Masahiko Hayashi; Kanki Komiyama; Toh-Seok Kam

doi:10.1021/np200008g

Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia

J Nat Prod. 2011 May 27;74(5):1309-12. doi: 10.1021/np200008g. Epub 2011 Mar 23.

Authors

Wai-Sum Yap¹, Chew-Yan Gan, Yun-Yee Low, Yeun-Mun Choo, Tadahiro Etoh, Masahiko Hayashi, Kanki Komiyama, Toh-Seok Kam

Affiliation

¹ Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

PMID: 21428274
DOI: 10.1021/np200008g

Abstract

Three new indole alkaloids (1-3), named grandilodines A-C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established using NMR and MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Apocynaceae / chemistry*
Drug Resistance, Multiple / drug effects
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology*
KB Cells
Molecular Structure
Vincristine / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Indole Alkaloids
grandilodine A
grandilodine B
grandilodine C
Vincristine