Influence of donor cytomegalovirus (CMV) status on severity of viral reactivation after allogeneic stem cell transplantation in CMV-seropositive recipients

Floor L Pietersma; Suzanne van Dorp; Monique C Minnema; Jürgen Kuball; Ellen Meijer; Rob Schuurman; Debbie van Baarle

doi:10.1093/cid/cir002

Influence of donor cytomegalovirus (CMV) status on severity of viral reactivation after allogeneic stem cell transplantation in CMV-seropositive recipients

Clin Infect Dis. 2011 Apr 1;52(7):e144-8. doi: 10.1093/cid/cir002.

Authors

Floor L Pietersma¹, Suzanne van Dorp, Monique C Minnema, Jürgen Kuball, Ellen Meijer, Rob Schuurman, Debbie van Baarle

Affiliation

¹ Deparment of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.

PMID: 21427386
DOI: 10.1093/cid/cir002

Abstract

We investigated the role of donor cytomegalovirus (CMV) serostatus on reactivation of CMV infection in CMV-infected transplant recipients. Reactivation of CMV infection occurred more frequently in patients receiving a CMV-positive graft but was less severe than in patients receiving a CMV-negative graft. These data suggest roles for both virus as well as CMV-specific immunity present in the graft.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytomegalovirus / immunology
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / immunology
Cytomegalovirus Infections / pathology*
Female
Humans
Incidence
Male
Middle Aged
Severity of Illness Index*
Stem Cell Transplantation*
Tissue Donors*
Virus Activation*