An efficient synthesis of dihydro- and tetrahydropyrans via oxonium-ene cyclization reaction

Org Biomol Chem. 2011 May 7;9(9):3428-38. doi: 10.1039/c1ob00033k. Epub 2011 Mar 22.

Abstract

An efficient method has been developed for the synthesis of 2,3-dihydropyrans and 4-methylenetetrahydropyrans from aldehydes and substituted homoallyl alcohols in benzene mediated by boron trifluoride etherate in good yields. The reaction proceeds via oxonium-ene reaction.