Revealing the nature of thio-click reactions on the solid phase

M Talha Gokmen; Jérémy Brassinne; R Arun Prasath; Filip E Du Prez

doi:10.1039/c0cc05340f

Revealing the nature of thio-click reactions on the solid phase

Chem Commun (Camb). 2011 Apr 28;47(16):4652-4. doi: 10.1039/c0cc05340f. Epub 2011 Mar 21.

Authors

M Talha Gokmen¹, Jérémy Brassinne, R Arun Prasath, Filip E Du Prez

Affiliation

¹ Department of Organic Chemistry, Polymer Chemistry Research Group, Ghent University, Krijgslaan 281 S4-bis, B-9000 Ghent, Belgium.

PMID: 21423975
DOI: 10.1039/c0cc05340f

Abstract

Thiol- and yne-functionalized beads were manufactured in a simple microfluidic setup. While CuAAC and thiol-yne reactions were performed on yne-functionalized beads, 9 different thiol-X reactions were compared, in terms of kinetics and conversion, on thiol-functionalized beads.

MeSH terms

Alkynes / chemical synthesis
Alkynes / chemistry*
Azides / chemistry
Catalysis
Copper / chemistry
Kinetics
Microfluidic Analytical Techniques
Molecular Structure
Organometallic Compounds / chemistry
Particle Size
Sulfhydryl Compounds / chemistry*
Surface Properties

Substances

Alkynes
Azides
Organometallic Compounds
Sulfhydryl Compounds
Copper