Objective: To evaluate the cerebrovascular reserve (CVR) in patients of ischemic stroke with cerebrovascular stenosis by Xenon-enhanced CT.
Methods: Twenty subjects of ischemic stroke with cerebrovascular stenosis were recruited. All subjects were examined by Xenon-enhanced CT before and after acetazolamide (ACZ) challenge test to quantitatively measure the regional cerebral blood flow (rCBF) and CVR.
Results: We compared the rCBF in the corresponding region supplied with stenosed artery (divided manually) with that in the region of normal side. There was no significant difference in resting rCBF but in CVR [ipsilateral side vs. normal side (5.9 ± 24.3)% vs (25.9 ± 32.6)%, P < 0.05].
Conclusion: Impaired CVR is an important character of the patients with cerebrovascular stenosis suffered from ischemic stroke.