Abstract
In Drosophila melanogasler,the wings apart-like (wapl) gene encodes a protein that regulates heterochromatin structure. Human wapl gene is human homolognue of wapl,they have same function. HWAPL is a cohesion-binding protein that affect chromosomal segregation. It has a character of oncoproteins and linked to cervical carcinogenesis and tumor progression.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carrier Proteins / genetics*
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Carrier Proteins / physiology*
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Cell Cycle Proteins / metabolism*
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Chromatids / metabolism*
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism*
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Chromosomal Proteins, Non-Histone / physiology
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Cohesins
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Drosophila Proteins / genetics
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Drosophila Proteins / physiology
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Female
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Humans
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Nuclear Proteins / genetics*
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Nuclear Proteins / physiology*
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / physiology*
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Uterine Cervical Neoplasms / genetics
Substances
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Carrier Proteins
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone
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Drosophila Proteins
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Nuclear Proteins
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Proto-Oncogene Proteins
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WAPL protein, human
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Wapl protein, Drosophila