A software-programmable microfluidic device for automated biology

Lab Chip. 2011 May 7;11(9):1612-9. doi: 10.1039/c0lc00537a. Epub 2011 Mar 17.

Abstract

Specific-purpose microfluidic devices have had considerable impact on the biological and chemical sciences, yet their use has largely remained limited to specialized laboratories. Here we present a general-purpose software-programmable microfluidic device which is capable of performing a multitude of low- and high-level functions without requiring any hardware modifications. To demonstrate the applicability and modularity of the device we implemented a variety of applications such as a microfluidic display, fluid metering and active mixing, surface immunoassays, and cell culture. We believe that analogously to personal computers, programmable, general-purpose devices will increase the accessibility and advance the pervasiveness of microfluidic technology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Automation / instrumentation*
  • Cell Culture Techniques / instrumentation
  • Equipment Design
  • Immunoassay / instrumentation
  • Microfluidic Analytical Techniques / instrumentation*
  • Microfluidic Analytical Techniques / methods
  • Microscopy, Fluorescence
  • Software*
  • Yeasts / chemistry
  • Yeasts / cytology