Abstract
Pure testicular seminoma is a rare disease with an excellent prognosis. Its management is controversial. In stage I disease, several treatment options are considered. Those are radiation therapy alone, chemotherapy alone or active surveillance, which is becoming increasingly popular. For more advanced stages, treatment is based on chemotherapy with or without radiation therapy. In this article, we review thoroughly the existing literature and recent recommendations the various treatment options, their advantages and disadvantages in different stages of the disease.
Copyright © 2010 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.
MeSH terms
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Adult
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Antineoplastic Agents, Alkylating / administration & dosage
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Antineoplastic Agents, Alkylating / therapeutic use
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Chorionic Gonadotropin, beta Subunit, Human / metabolism
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Combined Modality Therapy
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Disease Management
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Humans
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Lymphatic Irradiation
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Male
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Neoplasm Invasiveness
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Neoplasm Staging
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Neoplasms, Radiation-Induced / etiology
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Neoplasms, Second Primary / etiology
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Orchiectomy
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / therapeutic use
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Practice Guidelines as Topic
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Prognosis
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Radiation Tolerance
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Radiotherapy / adverse effects
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Radiotherapy / methods
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Retrospective Studies
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Risk Factors
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Seminoma / epidemiology
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Seminoma / metabolism
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Seminoma / pathology
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Seminoma / secondary
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Seminoma / therapy*
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Testicular Neoplasms / epidemiology
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Testicular Neoplasms / metabolism
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Testicular Neoplasms / pathology
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Testicular Neoplasms / therapy*
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Therapies, Investigational
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Young Adult
Substances
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Antineoplastic Agents, Alkylating
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Chorionic Gonadotropin, beta Subunit, Human
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Organoplatinum Compounds