Plant bioreactors for pharmaceuticals

Biotechnol Genet Eng Rev. 2008:25:363-80. doi: 10.5661/bger-25-363.

Abstract

Plant bioreactors are attractive expression systems for economic production of pharmaceuticals. Various plant expression systems or platforms have been tested with certain degrees of success over the past years. However, further development and improvement are needed for more effective plant bioreactors. In this review we first summarize recent progress in various plant bioreactor expression systems and then focus on discussing protein compartmentation to unique organelles and various strategies for developing better plant bioreactors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bioreactors*
  • Biotechnology
  • Cell Culture Techniques / methods
  • Chloroplasts / metabolism
  • Pharmaceutical Preparations / isolation & purification*
  • Plant Oils / metabolism
  • Plant Roots / metabolism
  • Plants, Genetically Modified / cytology
  • Plants, Genetically Modified / genetics*
  • Plants, Genetically Modified / metabolism*
  • Protease Inhibitors / metabolism
  • Protein Engineering / methods
  • Recombinant Proteins / biosynthesis*
  • Recombinant Proteins / genetics*
  • Recombinant Proteins / isolation & purification
  • Seeds / genetics
  • Seeds / metabolism
  • Vacuoles / metabolism

Substances

  • Pharmaceutical Preparations
  • Plant Oils
  • Protease Inhibitors
  • Recombinant Proteins