Exploration of the disease locus by a careful evaluation of the likelihood polynomial for pedigree data

J Hum Genet. 2011 May;56(5):383-9. doi: 10.1038/jhg.2011.24. Epub 2011 Mar 17.

Abstract

It is demonstrated through two case studies that a careful evaluation of the likelihood polynomial results in a more accurate localization of disease locus. The evaluation of the likelihood function as a polynomial enables more flexible exploration of the disease locus. Visualization by a contour plot of the function on a unit square of paternal and maternal recombination fractions along with a superimposed ellipsoid of the Fisher information matrix helps us to find a more accurate localization of the disease locus.

MeSH terms

  • Female
  • Genetic Loci
  • Glaucoma, Open-Angle / genetics*
  • Gout / genetics*
  • Humans
  • Hyperuricemia / genetics*
  • Kidney Diseases / genetics*
  • Lod Score
  • Male
  • Models, Genetic*
  • Pedigree*
  • Recombination, Genetic

Supplementary concepts

  • Juvenile gout