Four new polyoxygenated gorgosterols from the gorgonian Isis hippuris

Nat Prod Res. 2011 Mar;25(6):585-91. doi: 10.1080/14786419.2010.485303.

Abstract

Four new polyoxygenated steroids (1-4) together with four known ones (5-8) have been isolated from the gorgonian Isis hippuris. The structures of the new compounds have been elucidated by spectroscopic analysis and chemical conversion. All of the new steroids showed moderate cytotoxicity against cultured NBT-T2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Cell Line
  • Cholesterol / analogs & derivatives*
  • Cholesterol / chemistry
  • Cholesterol / isolation & purification
  • Drug Screening Assays, Antitumor
  • Inhibitory Concentration 50
  • Molecular Structure
  • Rats

Substances

  • gorgosterol
  • Cholesterol