An iminocoumarin-Cu(II) ensemble-based chemodosimeter toward thiols

Chem Commun (Camb). 2011 May 14;47(18):5142-4. doi: 10.1039/c1cc10672d. Epub 2011 Mar 15.

Abstract

An 'ensemble'-based fluoregenic chemodosimeter 1-Cu(II) for detection of thiols is reported. Complex 1-Cu(II) sensitively senses thiols followed by hydrolysis to give a marked fluorescence enhancement over other amino acids at pH 7.4 under aqueous media. Confocal microscopic imaging of complex 1-Cu(II) is also herewith demonstrated for cellular thiol detection in HepG2 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper / chemistry*
  • Coumarins / chemistry*
  • Crystallography, X-Ray
  • Fluorescence
  • Fluorescent Dyes / chemistry*
  • Hydrogen-Ion Concentration
  • Organometallic Compounds / chemistry*
  • Spectrometry, Fluorescence
  • Sulfhydryl Compounds / chemistry*

Substances

  • Coumarins
  • Fluorescent Dyes
  • Organometallic Compounds
  • Sulfhydryl Compounds
  • Copper