Abstract
1. Ca2+ uptake, Ca2(+)-dependent ATPase activity and halothane-induced Ca2+ release from the heavy sarcoplasmic reticulum fraction of muscle from malignant hyperthermia susceptible individuals are similar to those of normal human muscle. 2. Ca2(+)-induced Ca2+ release from the diseased muscle was increased by 13%.
MeSH terms
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Azides / pharmacology
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Biological Transport, Active / drug effects
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Calcium / metabolism*
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Calcium / pharmacology
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Calcium-Transporting ATPases / metabolism
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Dantrolene / pharmacology
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Halothane / pharmacology
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Humans
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In Vitro Techniques
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Malignant Hyperthermia / metabolism*
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Muscles / drug effects
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Muscles / metabolism*
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Phenylmethylsulfonyl Fluoride / pharmacology
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Sarcoplasmic Reticulum / drug effects
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Sarcoplasmic Reticulum / metabolism*
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Sodium Azide
Substances
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Azides
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Phenylmethylsulfonyl Fluoride
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Sodium Azide
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Calcium-Transporting ATPases
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Dantrolene
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Calcium
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Halothane