A comparative analysis of haemodynamics and blood gases has been performed in patients during either low-flow anaesthesia with xenon and nitrous oxide and high-flow nitrous oxide anaesthesia. Ninety five patients scheduled for endoscopic surgery were included and divided into three groups: a combined low-flow anaesthesia (30 women), a low-flow nitrous oxide anaesthesia (30 women) and a high-flow nitrous oxide anaesthesia using a semi-closed circuit (35 women). The study has shown a stimulating effect of xenon on haemodynamics during carboxyperitoneum and Trendelenburg position, a better oxygen transport performance and a lower consumption of opioids in this group. Those favourable changes enable the optimization of the oxygen transport in endoscopic surgery in gynaecology, and reduce the contraindications to endoscopic surgery.