The article represents a randomized comparative study including 100 patients from 21 to 34 years old who has underwent a laparoscopic surgery in V. I. Kulakov Research Center of Obstetrics, Gynaecology, and Perinatology in 2007-2009. Patients were anaesthetized either with a spinal anaesthesia at L3-L4 level with bupivacaine or with a multi-component general anaesthesia using fentanyl, midazolam, propofol, rocuronium and artificial lung ventilation. Assessment of the serum 8-isoprostaglandin F2alpha before the surgery and 2 hours after the end of surgery has shown the increase of this oxidative stress marker in the early post-surgery period. However, in spinal anaesthesia group, the increase was significantly lower, indicating a more physiological nature of this method of anaesthesia.