Abstract
The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in Streptomyces lydicus. Inactivation of slgZ led to a novel streptolydigin derivative. Overexpression of slgZ, slgM, or both in S. lydicus led to a considerable increase in streptolydigin production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Aminoglycosides / biosynthesis*
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Aspartic Acid / metabolism
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Biosynthetic Pathways / genetics*
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Gene Deletion
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Gene Expression
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Molecular Sequence Data
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Sequence Alignment
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Streptomyces / metabolism*
Substances
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Aminoglycosides
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Bacterial Proteins
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Aspartic Acid
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streptolydigin