Abstract
The aim of the present study was to investigate by immunohistochemistry the presence and distribution of the orexin system in the stomach and gut of fallow deer. Abundant orexin A-positive cells were localized in the middle and basal portions of the mucosal glands of the cardial and fundic regions of the stomach. In the same gastric areas, orexin B-positive cells were also found, mainly localized in the basal portion of glands. In the intestinal tract, orexin-containing cells were occasionally found in the duodenal epithelium and in the rectal intestinal glands. Immunoreactivity for orexin receptors, type 1 and 2 (OX1R and OX2R), was not detected in the same stomach regions. OX1R-immunopositivity was observed in the enteric neuron ganglia localized in the submucosal and muscular intestinal layers, while OX2R-immunopositivity was found close in contact with the cytoplasmic membrane of epithelial cells in the small intestine.
Copyright © 2011 Elsevier GmbH. All rights reserved.
MeSH terms
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Abomasum
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Animals
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Deer / anatomy & histology*
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Deer / metabolism
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Duodenum / cytology
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Duodenum / innervation
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Duodenum / metabolism*
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Enteric Nervous System / cytology
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Enteric Nervous System / metabolism
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Epithelial Cells / metabolism
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Female
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Ganglia, Autonomic / cytology
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Ganglia, Autonomic / metabolism
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Gastric Mucosa / metabolism*
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Gastrointestinal Tract / cytology
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Gastrointestinal Tract / innervation
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Gastrointestinal Tract / metabolism
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Intestinal Mucosa / cytology
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Intestinal Mucosa / metabolism
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Intracellular Signaling Peptides and Proteins / metabolism*
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Lower Gastrointestinal Tract / cytology
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Lower Gastrointestinal Tract / innervation
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Lower Gastrointestinal Tract / metabolism*
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Male
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Neuropeptides / metabolism*
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Orexin Receptors
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Orexins
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Organ Specificity
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Receptors, G-Protein-Coupled / metabolism*
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Receptors, Neuropeptide / metabolism*
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Stomach / cytology
Substances
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Orexin Receptors
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Orexins
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Receptors, G-Protein-Coupled
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Receptors, Neuropeptide