Design, synthesis and cytotoxic activities of novel β-amino alcohol derivatives

Bing Bai; Xing-Yao Li; Yan Li; Hua-Jie Zhu

doi:10.1016/j.bmcl.2011.02.087

Design, synthesis and cytotoxic activities of novel β-amino alcohol derivatives

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2302-4. doi: 10.1016/j.bmcl.2011.02.087. Epub 2011 Feb 26.

Authors

Bing Bai¹, Xing-Yao Li, Yan Li, Hua-Jie Zhu

Affiliation

¹ Organic Synthesis and Natural Product Laboratory, Kunming Institute of Botany, Chinese Academic of Sciences, Kunming 650204, PR China.

PMID: 21397498
DOI: 10.1016/j.bmcl.2011.02.087

Abstract

Three series of novel β-amino alcohols possessing an N-anthranyl group have been obtained using tryptophan as the major starting material. These compounds were screened for cytotoxic activity against five human cancer cell lines in vitro by MTT assay, and some of them exhibited potential ability to be anticancer agents. Structure-activity relationship was carefully investigated. Only the compounds possessing small substituents (H or CH(3)) at C-6 position showed the same activity as cisplatin (DDP) did.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Alcohols / chemistry*
Amino Alcohols / therapeutic use
Amino Alcohols / toxicity
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / therapeutic use
Antineoplastic Agents / toxicity
Cell Line, Tumor
Drug Design
Drug Screening Assays, Antitumor
Humans
Neoplasms / drug therapy
Structure-Activity Relationship

Substances

Amino Alcohols
Antineoplastic Agents