New S-benzylisothiosemicarbazones with antimycobacterial activity

E Petrlíková; K Waisser; L Heinisch; J Stolaříková

doi:10.1007/s12223-011-0015-3

New S-benzylisothiosemicarbazones with antimycobacterial activity

Folia Microbiol (Praha). 2011 Jan;56(1):10-2. doi: 10.1007/s12223-011-0015-3. Epub 2011 Mar 11.

Authors

E Petrlíková¹, K Waisser, L Heinisch, J Stolaříková

Affiliation

¹ Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, 500 05, Hradec Králové, Czech Republic. Eva.Petrlikova@faf.cuni.cz

PMID: 21394476
DOI: 10.1007/s12223-011-0015-3

Abstract

Benzaldehyde- and salicylaldehyde-S-benzylisothiosemicarbazones show a moderate to high in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. Benzaldehyde-S-4-bromobenzylisothiosemicarbazone and salicylaldehyde-S-4-chlorobenzylisothiosemicarbazone have the most promising antimycobacterial properties.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology*
Humans
Mycobacterium avium / drug effects*
Mycobacterium kansasii / drug effects*
Mycobacterium tuberculosis / drug effects*
Phenols / chemistry
Phenols / pharmacology*
Structure-Activity Relationship
Thiosemicarbazones / chemistry
Thiosemicarbazones / pharmacology*
Tuberculosis / microbiology

Substances

Antitubercular Agents
Phenols
Thiosemicarbazones