Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation

Yutaka Aoyagi; Yoshiyuki Adachi; Kei Ozawa; Chihiro Yokomizo; Ming-Yu Gui; Yong-Ri Jin; Xu-Wen Li; Naohito Ohno; Koichi Takeya

doi:10.1016/j.bmc.2011.02.002

Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation

Bioorg Med Chem. 2011 Apr 1;19(7):2450-7. doi: 10.1016/j.bmc.2011.02.002. Epub 2011 Feb 16.

Authors

Yutaka Aoyagi¹, Yoshiyuki Adachi, Kei Ozawa, Chihiro Yokomizo, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Naohito Ohno, Koichi Takeya

Affiliation

¹ School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

PMID: 21393004
DOI: 10.1016/j.bmc.2011.02.002

Abstract

A series of rabdokunmin C analogues were prepared and their inhibitory effect on NF-κB activation was assayed. One of them, 18-acetyl-12-deoxy-11,12-dehydrorabdokunmin C (16) was found to be a promising candidate for an anti-inflammatory agent.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Diterpenes / chemical synthesis*
Diterpenes / pharmacology*
Diterpenes, Kaurane / chemical synthesis
Diterpenes, Kaurane / pharmacology
Hep G2 Cells
Humans
Leukemia P388 / drug therapy
Macrophages / drug effects
Mice
NF-kappa B / genetics
NF-kappa B / metabolism*
Structure-Activity Relationship

Substances

Diterpenes
Diterpenes, Kaurane
NF-kappa B
kaurene