Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives

Shuxiang Wang; Wenqing Shao; Hongdong Li; Cui Liu; Ke Wang; Jinchao Zhang

doi:10.1016/j.ejmech.2011.02.031

Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives

Eur J Med Chem. 2011 May;46(5):1914-8. doi: 10.1016/j.ejmech.2011.02.031. Epub 2011 Feb 22.

Authors

Shuxiang Wang¹, Wenqing Shao, Hongdong Li, Cui Liu, Ke Wang, Jinchao Zhang

Affiliation

¹ Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei, PR China. wsx@hbu.edu.cn

PMID: 21392862
DOI: 10.1016/j.ejmech.2011.02.031

Abstract

Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5-dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV, 1H NMR, 13C NMR, MS, and thermal analysis techniques. The cytotoxicity was tested by MTT assay. The results indicate that the complexes 1-8 exert cytotoxic effects against HeLa and A549 cell lines. Moreover, the complexes 1, 4, 5, 7 and 8 have higher cytotoxicity than cisplatin against HeLa cell line. It suggests that the substituent groups on benzene have important effect on cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Gold / chemistry*
HeLa Cells
Humans
Ligands
Molecular Structure
Organogold Compounds / chemical synthesis
Organogold Compounds / chemistry
Organogold Compounds / pharmacology*
Pyrazoles / chemistry*
Stereoisomerism
Structure-Activity Relationship
Temperature
Thioamides / chemistry*
Tumor Cells, Cultured

Substances

4,5-dihydropyrazole-1-carbothioamide
Antineoplastic Agents
Ligands
Organogold Compounds
Pyrazoles
Thioamides
Gold