An effective DNA-based electrochemical switch for reagentless detection of living cells

Chem Commun (Camb). 2011 Apr 21;47(15):4388-90. doi: 10.1039/c1cc10430f. Epub 2011 Mar 9.

Abstract

A novel switch-cytosensing strategy has been designed, which is based on the changes of electron transfer efficiency between ferrocene at the end of DNA and the electrode surface before and after cell transfection. This strategy provided a general and convenient method to fabricate efficient electrochemical cell sensors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods*
  • Cell Line
  • Cell Survival
  • Cells, Immobilized / cytology
  • Cells, Immobilized / metabolism
  • DNA / chemistry*
  • DNA / metabolism
  • DNA Probes / chemistry
  • DNA Probes / metabolism
  • Electrochemistry
  • Electrodes
  • Ferrous Compounds / chemistry
  • Gold / chemistry
  • Metallocenes
  • Transfection

Substances

  • DNA Probes
  • Ferrous Compounds
  • Metallocenes
  • Gold
  • DNA
  • ferrocene