Recurrent community-acquired methicillin-resistant Staphylococcus aureus infections in an HIV-infected person

J Clin Microbiol. 2011 May;49(5):2047-53. doi: 10.1128/JCM.02423-10. Epub 2011 Mar 9.

Abstract

HIV-infected persons are at heightened risk for recurrent community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections, but there are limited data regarding the molecular characterization of these events. We describe an HIV-infected patient with 24 soft tissue infections and multiple colonization events. Molecular genotyping from 33 nonduplicate isolates showed all strains were USA300, Panton-Valentine leukocidin (PVL) and arginine catabolic mobile element (ACME) positive, and genetically related.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Bacterial Toxins / genetics
  • Bacterial Typing Techniques
  • Cluster Analysis
  • Community-Acquired Infections / diagnosis*
  • Community-Acquired Infections / microbiology
  • Electrophoresis, Gel, Pulsed-Field
  • Exotoxins / genetics
  • Genotype
  • HIV Infections / complications*
  • Humans
  • Interspersed Repetitive Sequences
  • Leukocidins / genetics
  • Male
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification*
  • Molecular Typing
  • Recurrence
  • Staphylococcal Infections / diagnosis*
  • Staphylococcal Infections / microbiology
  • Virulence Factors / genetics

Substances

  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin
  • Virulence Factors