Maklamicin, an antibacterial polyketide from an endophytic Micromonospora sp

Yasuhiro Igarashi; Hiromu Ogura; Kazuo Furihata; Naoya Oku; Chantra Indananda; Arinthip Thamchaipenet

doi:10.1021/np100727h

Maklamicin, an antibacterial polyketide from an endophytic Micromonospora sp

J Nat Prod. 2011 Apr 25;74(4):670-4. doi: 10.1021/np100727h. Epub 2011 Mar 9.

Authors

Yasuhiro Igarashi¹, Hiromu Ogura, Kazuo Furihata, Naoya Oku, Chantra Indananda, Arinthip Thamchaipenet

Affiliation

¹ Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp

PMID: 21388191
DOI: 10.1021/np100727h

Abstract

A new spirotetronate-class polyketide, maklamicin (1), was isolated from the culture extract of an endophytic actinomycete of the genus Micromonospora. The structure and relative configuration of 1 were elucidated by interpretation of NMR and other spectroscopic data, and the absolute configuration was determined using the modified Mosher method. Maklamicin (1) showed strong to modest antimicrobial activity against Gram-positive bacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abrus / microbiology
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology*
Bacillus cereus / drug effects
Bacillus subtilis / drug effects
Drug Screening Assays, Antitumor
Enterococcus faecalis / drug effects
Gram-Positive Bacteria / drug effects
HeLa Cells
Humans
Macrolides / chemistry
Macrolides / isolation & purification*
Macrolides / pharmacology*
Microbial Sensitivity Tests
Micrococcus luteus / drug effects
Micromonospora / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Macrolides
maklamicin