Abstract
Osteoporosis is the most common systemic skeletal disease characterized by low bone mass, increased bone turnover, and subsequent increased susceptibility to fracture. The aim of this paper was to present a molecular basis of bone remodeling, pathogenesis and different types of osteoporosis. Diagnostic studies, including bone densitometry and laboratory analysis were also reviewed.
MeSH terms
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Alkaline Phosphatase / metabolism
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Biomarkers / metabolism
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Bone Density
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Bone Remodeling / physiology*
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Bone and Bones / physiopathology
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Calcium / blood
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Calcium / therapeutic use
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Collagen Type I / metabolism
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Female
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Fractures, Bone / etiology
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Fractures, Bone / physiopathology
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Fractures, Bone / prevention & control
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Humans
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Hydroxyproline / metabolism
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Male
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Osteoporosis / complications
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Osteoporosis / diagnosis*
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Osteoporosis / physiopathology*
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Osteoporosis / prevention & control
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Osteoprotegerin / metabolism
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Parathyroid Hormone / metabolism
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Risk Factors
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Vitamin D / metabolism
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Vitamin D / therapeutic use
Substances
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Biomarkers
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Collagen Type I
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Osteoprotegerin
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Parathyroid Hormone
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Vitamin D
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Alkaline Phosphatase
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Hydroxyproline
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Calcium